Prenatal lack of omega-3 and omega-6 fatty acids linked to schizophrenic symptoms in mice
Researchers have discovered a process through which changes in nutrition during early mouse pregnancy lead to offspring that develop schizophrenic-like symptoms as adults. The study shows how deprivation of two polyunsaturated fatty acids during early gestation can have long lasting effects on offspring through specific epigenetic changes in gene expression.
M Maekawa, A Watanabe, Y Iwayama, T Kimura, K Hamazaki, S Balan, H Ohba, Y Hisano, Y Nozaki, T Ohnishi, M Toyoshima, C Shimamoto, K Iwamoto, M Bundo, N Osumi, E Takahashi, A Takashima, T Yoshikawa. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Translational Psychiatry, 2017; 7 (9): e1229 - Website