Human Milk Oligosaccharides (HMO)
Bioactive nutrition: Human milk and milk-derived oligosaccharides
HMO* and MOS promote a gut microbiome closer to breastfed infants including an increase in bifidobacteria. HMO* and MOS decrease the abundance of potentially and opportunistic pathogenic bacteria in the microbiome, respectively. HMO* significantly reduced illness (LRTI and bronchitis) and antibiotic use through 12 months of age. MOS enhances intestinal immunity and GI barrier integrity/permeability.
The Role of Oligosaccharides on the Immune System and Long-term Outcomes
The viewer should have an augmented understanding of the importance of oligosaccharides in human health.
The Gut Microbiome, its Metabolome, and Their Relationship to Health and Disease
Key concepts that the gut microbiota may be related to health and disease were illustrated using IBD as an example.
Everyone's talking about human milk oligosaccharides
The early-life gut microbiome is important for the development of immune competence in newborn infants. Mode of delivery, perinatal antibiotic use and diet are most influential to this end. Breastfeeding is associated with lower risk of gastrointestinal and respiratory infections, and possibly lower risk of diabetes and obesity, while the effect on allergies is not so clear. This suggests that breast milk-specific components may contribute. Among them are the non-digestible human milk oligosaccharides (HMOs), the third largest solid breast milk component that varies primarily due to the maternal genotype for the Secretor and Lewis genes and stage of lactation. Other milk oligosaccharides are also relevant here.
Feeding Oligosaccharides (prebiotics) to the Preterm Infant
Importance of feeding prebiotics to preterm infants. To reduction stool viscosity, improvement of gastrointestinal transit, positive effect on gut flora, less serious neonatal infections.