Allergies - immunity
The Microbe-gut–brain Connection: Study Highlights the Importance of Gut Microbiota in Neurodevelopment
A recent study explored the relationship between early-life gut microbiota and neurodevelopment in mice. This study suggests that exposure to antibiotics during early life can change the gut microbiota, leading to a subtle but long-lasting impact on the gut–brain–immune axis. Antibiotic-induced gut microbial depletion has a sex- and time-dependent effect on circulating immune cells. Furthermore, even brief exposure to antibiotics in early life can have a significant effect on the composition and structure of the developing gut microbiota, reducing its diversity and changing the abundance of certain microorganisms, potentially impacting behaviour, neuroimmune function, and neurodevelopment. To promote positive neurodevelopmental and behavioural outcomes in later life, it is essential to maintain gut microbial diversity and stability during the critical window of early life. These findings highlight the importance of careful consideration when administering antibiotics and lay the groundwork for developing strategies to support a healthy gut microbiome in early life.
New Research Uncovers Benefits of Breastfeeding for Asthma Prevention
A recent study demonstrates the advantages of breastfeeding in lowering the incidence of paediatric asthma after antibiotic treatment. According to the study, breastfed infants had a threefold reduced chance of developing asthma after antibiotic treatment than those who were not. Fucosylated human milk oligosaccharides (HMOs), one of the bioactive components of breastmilk, were positively linked to the enrichment of Bifidobacter infantis (B. infantis) in the infant gut microbiota. This was associated with a lower incidence of asthma. The study adds to the understanding of how HMOs found in breastmilk, and B. infantis can protect kids against asthma and pave the way for the development of novel treatments to promote infant gut health and lower asthma risk in children.
Bioactive Nutrition - A focus on Osteopontin
In this, the latest in our series on bioactive nutrition, we discuss the role of the bioactive protein osteopontin. Osteopontin plays a role in several biological processes including immune function and is present in most tissues and bodily fluids, with the highest concentration found in milk.
Family risk for childhood asthma may involve microbes found in baby's digestive tract
A new University of Alberta study shows that the family risk for asthma - typically passed from moms to babies-may not be a result of genetics alone: it may also involve the microbes found in a baby's digestive tract.
The Host Defense Proteome Of Human And Bovine Milk
First detailed analysis of milk host defense proteins, important in understanding their function in the development of the immune system.
Swat team of immune cells found in mother's milk
Immune cells that are ready to take action against invaders like bacteria have been found in women's breast milk, researchers say. They say the presence of this SWAT team of immune cells called innate lymphoid cells, or ILCs, in human breast milk is more evidence of the benefits of breastfeeding. Short term, the ILCs in breast milk may help protect newborns from infection, and longer term help babies develop their own protective immune system, they report in JAMA Pediatrics.